Faculty Contact Info

OFFICE:  835 S Wolcott

         E411 MSB

PH #:  (312) 355-0236

EMAIL:  dmehta@uic.edu


LAB PAGE​​​​​​​

Dolly Mehta  PhD

PROFESSOR OF PHARMACOLOGY

Research Interests 

The overall goal of my lab is to identify the signaling "switches" that induce endothelial cell contraction and compromise endothelial barrier function, and those that turn off endothelial contraction, promoting barrier repair.


Specific projects are:


1) Investigating the role of PTEN and transient receptor potential channel (TRPC) primarily TRPC6 in regulating calcium entry in endothelial cells and in inducing cytosketal re-organization and subsequently the loss of endothelial barrier function and induction of pulmonary inflammatory signaling.  


2)   Addressing the novel role of endothelial focal adhesion kinase (FAK) in resolving lung vascular barrier function and in moderating inflammation through microRNA-150 suppression of STIM1 (an endoplasmic reticulum calcium sensor).


3)  Determining the role of functional coupling between TRPC6 and TRPC1 as induced by myosin light chain kinase and STIM1 in regulating calcium entry and lung vascular injury and inflammatory signaling.


4) Determining crosstalk between TRPC and FAK with sphingosine kinase (SPHK), a regulatory switch that antagonizes thrombin-induced increase in endothelial permeability by generating S1P

Selected Awards and Honors

1998-2001

2003-2009

2010-2014

2014-

Member NIH Respiratory Integrative Biology and Translational Research Study Section

Giles Filley Award for Excellency in Physiology, American Physiological Society

Member NIH NHLBI RIBT Study Section

Associate Editor, The American Journal of Physiology-Lung Cellular and Molecular Physiology​​​​​​​

Selected Publications

Yazbeck P, Tauseef M, Kruse K, Amin MR, Sheikh R, Feske S, Komarova Y, Mehta D. STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry. Sci Rep. 2017 Feb 20;7:42758.


Rajput C, Tauseef M, Farazuddin M, Yazbeck P, Amin MR, Avin Br V, Sharma T, Mehta D. MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular Injury. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):380-8.


Tauseef M, Farazuddin M, Sukriti S, Rajput C, Meyer JO, Ramasamy SK, Mehta D. Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability. FASEB J. 2016 Jan;30(1):102-10.


Rajput C, Kini V, Smith M, Yazbeck Y, Chavez A, Thennes T, Knezevic N, Mehta D. N-WASP plays a critical role in re-annealing VE-cadherin adherens junctions. J Biol Chem. 288:4241-50, 2013.


Tauseef M, Knezevic N, Chava KR, Smith M, Sukriti S,Gianaris N, Obukhov AG, Vogel SM, Schraufnagel DE, Dietrich A, Birnbaumer L, Malik AB, Mehta D. TLR4 Activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation. J Exp Med. 209:1953-68, 2012.


Chava KR, Tauseef M, Mehta D. Cyclic AMP response element binding (CREB) protein prevents endothelial  permeability increase through transcriptional controlling p190RhoGAP expression. Blood. 119:308-19, 2012.


Kini V, Chavez A, Mehta D. A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability and angiogenesis. J Biol Chem. 285:33082-91, 2010.


Knezevic N, Tauseef M, Thennes T, Mehta D.The G protein beta gamma subunit mediates re-annealing of adherens junctions to reverse endothelial permeability increase by thrombin. J Exp Med. 206:2761-77, 2009.


Tauseef M, Kini V, Knezevic N, Saba J, Vogel S, Ramchandran R, Malik AB, Mehta D.  Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res.103:1164-72, 2008.


Nebojsa K, Roy A, Timblin B, Konstantoulaki M, Malik AB, Mehta D. Requirement for GDI-1 phosphorylation at  serine 96 in the mechanism of RhoA activation and increased endothelial permeability. Mol Cell Biol. 27:6323-33, 2007.


Holinstat M, Knezevic N, Broman M, Samarel A, Malik AB, Mehta D. Suppression of rho activity by focal adhesion kinase-induced activation of p190RhoGAP: Role in restoring endothelial barrier function. J Biol Chem. 281:2296-305, 2006.


Jho DH, Mehta D., Ahmmed G, Gao X-P, Tiruppathi C, Broman MT, Malik AB. Angiopoietin-1 apposes VEGF-induced increase in endothelial permeability by inhibiting calcium entry through TRPC channels. Circ Res. 96:1282-90, 2005.


Mehta D., Konstantoulaki M, Ahmmed GU, Malik AB. Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates Rac activation and adherens junction assembly in endothelial cells. J Biol Chem. 280:17320-8, 2005.