Faculty Contact Info

OFFICE:  909 S Wolcott Ave

       4135 COMRB

PH #:  (312) 355-4439

EMAIL:  kvp@uic.edu

LAB PAGE​​​​​​​

Kostandin Pajcini, PhD



Please send CVs to kvp@uic.edu

Research Interests

Research in my laboratory focuses on the role of cell signaling in hematopoietic development and disorders. We study the Notch signaling pathway and its role in regulating the development and cell fate decisions of fetal hematopoietic stem cells (HSC) in mouse models. The overall goal is to understand the molecular and signaling cues that allow for the vast regeneration potential of fetal HSCs and to develop biomedical approaches that will allow adult bone-marrow HSCs to self-renew and expand with the same potency as fetal HSCs.

To accomplish these goals, we rely on transgenic mouse models in timed matings followed by embryonic dissection of hematopoietic organs. We use these strategies to accurately detect the hematopoietic development in the mammalian system. Ultimately, through flow cytometry analysis and sorting, we obtain information from single cells for gene expression as well as functional analysis via transplantation to recipient mice.

By learning the physiologically relevant signaling events in vivo we aim to modulate the signaling strength that blood cells receive by retrovirally transducing transcription factors and converting cell fates of hematopoietic cells or expanding the stem cell pool ex vivo for clinical applications.​​​​​​​

Selected Publications

Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen M, Rentschler S, Shestova O, Wertheim G, Aster JC, Gimotty PA, Speck NA, Bigas A, Pear WS. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes and Development. 28(6):576-593, 2014.

Pajcini KV, Corbel SY, Pomerantz JH, Sage J, Blau HM. Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell. 7(2):198-213, 2010.