Contact Info

OFFICE:  909 S Wolcott

              4040 COMRB

PH #:  (312) 355-0251


Zhigang Hong, MD, PhD


Research Interests

My research aims to study new mechanisms and new treatments for acute lung injury. The following are a few of my current research interests:

1) To study VE-PTP-mediated regulation of adherens junctions: including VE-cadherin stabilization, internalization and recycling in acute lung injury.

2) To study new mechanisms of lung vascular hyper-permeability and edema resulting from left heart failure.

3) To study new mechanisms of acute lung injury by RiboTag procedure. 

Selected Awards and Honors


Actelion Young Investigators Award

Selected Publications

Zhang L, Jambusaria A, Hong Z, et al. SOX17 Regulates Conversion of Human Fibroblasts into Endothelial Cells and Erythroblasts via De-Differentiation into CD34+ Progenitor Cells. Circulation 2017.

Hong Z, Chen KH, Dasgupta A, et al. MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype. American Journal of Respiratory and Critical Care Medicine, 2017;195(4):515-529.

Hong Z, Cabrera JA, Mahapatra S, et al. Activation of the EGFR/p38 /JNK Pathway by Mitochondrial-Derived Hydrogen Peroxide Contributes to Oxygen-induced Contraction of Ductus Arteriosus. Journal of Molecular Medicine 2014; 92(9): 995-1007

Hong Z, Kutty S, Toth PT, et al. Obligatory Role of Dynamin Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Oxygen-Sensing, Constriction and Closure of the Human Ductus Arteriosus. Circulation Research 2013 112(5): 802-815.  

Marsboom G, Toth PT, Ryan J, Hong Z, et al. Dynamin-Related Protein 1 (DRP1)-Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension. Circulation Research 2012:  110(11):1484-1497.

Varghese A, Hong Z, Weir EK. Serotonin-induced inhibition of Kv current: a supporting role in pulmonary vasoconstriction? Circulation Research 2006; 98: 860-862.

Hong Z, Hong F, Olschewski A, et al. Role of store-operated calcium channels and calcium sensitization are involved in normoxic contraction of the ductus arteriosus. Circulation 2006; 114: 1372-1379. PMID 16982938.

Ross JJ, Hong Z, Willenbring B, et al.  Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells. J. Clin. Invest. 2006; 116: 3139-3149.

Hong Z, Smith AJ, Archer SL, et al. Pergolide is an inhibitor of voltage gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction. Circulation 2005; 112: 1494 – 1499