Xiaoping Du, MD, PhD

PROFESSOR OF PHARMACOLOGY

Research Interests

Research interests of my laboratory are in the field of thrombosis, hemostasis, and vascular biology. Specifically, we study cell adhesion and signaling, including: 1) signaling mechanisms of platelet adhesion receptor, glycoprotein Ib-IX.  2) signaling mechanisms of integrins, particularly β3 integrins. 3) role of GTP binding proteins in platelet activation, and 4) role of nitric oxide-cGMP-dependent signaling pathway in regulating platelet function.

Selected Awards and Honors

Selected Publications

Shen B, Zhao X, O'Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SC, Du X. A directional switch of integrin signalling and a new anti-thrombotic strategy. Nature. 503:131-135, 2013.

Yin H, Stojanovic-Terpo A, Xu W, Corken A, Zakharov A, Qian F, Pavlovic S, Krbanjevic A, Lyubimov AV, Wang ZJ, Ware J, Du X. Role for Platelet Glycoprotein Ib-IX and Effects of its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality. Arterioscler Thromb Vasc Biol. 33:2529-2537, 2013.

Estevez B, Stojanovic-Terpo A, Delaney MK, O'Brien KA, Berndt MC, Ruan C, Du X. LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood. 121:4586-94, 2013.

Gong H, Shen B, Flevaris P, Chow C, Lam S C-T, Voyno-Yasenetskaya T, Kozasa T, Du X. G protein subunit Ga13 binds to integrin aIIbb3 and mediates integrin “outside-in” signaling. Science. 327:340-343, 2010.

Yin H, Stojanovic A, Hay N, Du X. The role of Akt in the VWF/GPIb-IX-induced platelet activation. Blood. 111:658-665, 2008.

Xi X, Bodnar RJ, Li Z, Lam S C-T, Du X. Critical roles for the NITY and RGT sequences of the integrin b3 cytoplasmic domain in inside-out and outside-in signaling. J Cell Biol. 162:329-339, 2003.

Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofmann F, Du X. A stimulatory role for the cGMP-dependent protein kinase in platelet activation. Cell. 112: 77-86, 2003

Complete List of Publications