Inflammation protects the body from infection and simultaneously causes damage to multiple organs thereby endangering the host. We try to learn more about the mechanisms that control the organ damaging inflammatory responses.

My project will be to study innate immune memory in lung inflammation.

Determine the role of regulated exocytosis in immune cells and determine the role of ion channel expression and its function.

Investigating molecular pathways that regulate lymphatic development and function during edema.

Generation of vascularized complex human lung organoids from stem cells to uncover the mechanism of lung development and use this platform for different lung disease modelling. Role of endothelium in the SARS-CoV2 infection and pathogenesis of COVID-19.

Studying the effects of mechanical stimuli on cells using microfluidic systems. Investigating how the PECAM-1 homophilic interaction contributes to the transendothelial migration of neutrophils.

Investigating how activation of the endothelial TRPM2 channel by oxidants mediates lung vascular injury. 

Vascular Biology

Lung Biology & Pathophysiology

Inflammation Signaling Mechanisms

Cell Receptors & Signaling

Stem Cell Biology & Regenerative Medicine