MEDICAL PHARMACOLOGY COURSE DIRECTOR
Kishore Wary, PhD
RESEARCH PROFESSOR
The aim of my research is to improve human health by delineating the molecular mechanisms of endothelial cells phenotypes in development and disease settings. I have acquired 15+ years of experience investigating the mechanisms of integrin signaling and angiogenesis. In recent years, my laboratory has started investigating the role of Wnt signaling, Notch, and Nanog in relation to angiogenesis and organ regeneration.
Our team first identified Nanog in endothelial cells and we have shown that Nanog is a downstream component of canonical Wnt3a signaling, along the way we have amassed many critical reagents to study Nanog (e.g. Nanogfl/wt mice, antibodies, viral constructs etc).
We have technical expertise of high- and lowresolution microscopy, modern cell and molecular biology, and phenotyping the pathophysiological angiogenesis, including hind limb ischemia (HLI), tumor angiogenesis, and acute myocardial infarction (AMI), and sepsis induced acute lung injury (ALI).
My research is focused on the underlying mechanisms of pathophysiology, vascular biology, angiogenesis and tumor progression.
OFFICE: 4139 COMRB
PH #: (312) 413-9582
EMAIL: kkwary@uic.edu
PCOL 501 and 502 Medical Pharmacology I & II
The word ‘Pharmacology’ has its roots in Greek and stands for the study of drugs (pharmacon = poison/drug and logia = the study of). A drug is a substance generally used as a medicine or for diagnosis, or for prevention of a disease or for its physiological and behavioral effects. It can be “man-made”, endogenous (within the body), or naturally occurring.
Pharmacology in a classic sense can be divided into two broad areas- pharmacokinetics and pharmacodynamics. Pharmacokinetics is the study of how our body processes drugs, including their absorption, distribution, metabolism and excretion; and pharmacodynamics is the study of the effects of the drug on biological systems at molecular and physiological levels, and includes the mechanism of a drug’s action, side effects, and interactions with other drugs or endogenous substances . Therapeutics, is the application of the principles of pharmacology to the treatment of disease and patient care.
The Medical Pharmacology course is taught to second- year medical students, and spans the entire academic year. This team- taught course is lecture-based, with team-based learning sessions. Although course doesn’t or cannot to cover every existing drug, students are introduced to all major classes of drugs, clinical uses, underlying pharmacokinetic principles, mechanism of action, metabolism, and side effects. Students have access to all the necessary teaching material through their black board accounts.