Faculty Contact Info
POSTDOCTORAL & LAB TECHNICIAN POSITIONS CURRENTLY AVAILABLE
Please send CVs to sangging@uic.edu
Sang Ging Ong, PhD
ASSISTANT PROFESSOR OF PHARMACOLOGY AND MEDICINE
B.S., University of Technology, Malaysia; Industrial Biology (2006).
M.S., University of Manchester, U.K.; Biological sciences (2008).
PhD, University College London, U.K.; Cardiovascular Sciences (2011).
Postdoc, Stanford University, U.S.A.; Stem cells/iPSCs (2018).
Research Interests
The Ong Lab investigates a range of research topics, all of which center on deciphering the molecular mechanisms of cardiovascular disease and dysfunction and using this information to develop potential therapeutic strategies. Toward this end, we use human induced pluripotent stem cells as a platform to study the pathogenesis of cardiovascular diseases through cellular, genetic, and biochemical approaches. We are particularly interested in cardiometabolic diseases with a focus on mitochondrial biology. We also employ clinical samples and rodent models for our studies as additional validation steps.
We are also interested in investigating the biology of myocardial infarction, including developing cardioprotective strategies involving the mitochondrial permeability transition pore, stem cells for regenerative medicine, and exosomes in mediating myocardial repair.
Selected Publications
Kodo K*, Ong SG*, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC. iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy. Nat Cell Biol 2016. PMID: 27642787. *Co-first authors
Ong SG, Huber BC, Lee WH, Kodo K, Ebert AD, Ma Y, Nguyen PK, Diecke S, Chen WY, Wu JC. Microfluidic single-cell analysis of transplanted human induced pluripotent stem cell-derived cardiomyocytes after acute myocardial infarction. Circulation 2015. PMID: 26304668.
Lee WH, Chen WY, Shao NY, Xiao D, Qin X, Baker N, Bae HR, Wei TT, Wang Y, Shukla P, Wu H, Kodo K, Ong SG*, Wu JC*. Comparison of Non-Coding RNAs in Exosomes and Functional Efficacy of Human Embryonic Stem Cell- versus Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells 2017. PMID: 28710827. *Co-senior authors
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med 2016. PMID: 27089514.
Ong SG, Wu JC. Exosomes as potential alternatives to stem cell therapy in mediating cardiac regeneration. Circ Res 2015. PMID: 26089361.
Ong SG, Lee WH, Huang M, Dey D, Kodo K, Sanchez-Freire V, Gold JD, Wu JC. Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer. Circulation 2014. PMID: 25200057.
Ong SG, Lee WH, Theodorou L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson SM, Maxwell PH, Yellon DM, Hausenloy DJ. HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. Cardiovasc Res 2014. PMID: 25063991.
Keeney M*, Ong SG*, Padilla A, Yao Z, Goodman S, Wu JC, Yang F. Development of poly(β-amino ester)-based biodegradable nanoparticles for nonviral delivery of minicircle DNA. ACS Nano 2013. PMID: 23837668. *Co-first authors
Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Proc Natl Acad Sci U S A 2016. PMID: 27799523