Jiang Y, Krantz S, Qin X, Li S, Gunasekara H, Kim Y-M, Zimnicka A, Bae M, Ma K, Toth PT, Hu Y, Shajahan-Haq A, Patel HH, Gentile S, Bonini MG, Rehman J, Liu Y and Minshall RD. Caveolin-1 Controls Mitochondrial Damage and ROS Production by Regulating Fission-Fusion Dynamics and Mitophagy. Redox Biol. 2022 Apr 6;52:102304. doi: 10.1016/j.redox.2022.102304. PMCID: PMC9018165

Chen Z, Haus JM, Chen L, Jiang Y, Sverdlov M, DiPietro L, Wu S, Koh TJ, Minshall RD. Inhibition of CCL28/CCR10-mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-induced Mouse Model of Type 2 Diabetes. Diabetes 2022;71:1–15. https://doi.org/10.2337/db21-1108. PMID: 35899992

Jiang Y, Senyuk V, Ma K, Chen H, Qin X, Li S, Liu Y, Gentile S. Minshall RD. Pharmacological Activation of Potassium Channel Kv11.1 with NS1643 Attenuates Triple Negative Breast Cancer Cell Migration by Promoting the Dephosphorylation of Caveolin-1. Cells 2022 Aug 8;11(15):2461. PMCID: PMC9368491.

Le Master E, Paul A, Lazarko D, Aguilar V, Ahn SJ, Lee JC, Minshall RD, Levitan I. Caveolin-1 is a Primary Determinant of Endothelial Stiffening associated with Dyslipidemia, Disturbed Flow, and Ageing. Sci Rep 2022 Oct 24;12(1):17822. doi: 10.1038/s41598-022-20713-7. PMCID: PMC9592578.

Erewele EO, Castellon M, Marsboom G, Schwartz A, Yerlioglu K, Callahan C, Chen J, Minshall RD‡, Oliveira SD‡. Role of Hypoxia-induced Upregulation of eNOS and TGF-β in Sex-linked Pulmonary Hypertension in the BMPR2+/R899x Mutant Mouse Model. Pulm Circ Oct 1;12(4):e12163, 2022. PMCID: PMC9722973

Shetti AU, Ramakrishnan A, Romanova L, Li W, Vo K, Voleti I, Ratnayake I, Minshall RD‡, Cologna SM, Lazarov O‡. Reduced Endothelial Cell-specific Caveolin-1 Expression Underlies Deficits in Brain Insulin Signaling in the Obesity-induced Mouse Model of Type 2 Diabetes. Brain 2023 Feb 3:awad028. doi: 10.1093/brain/awad028. Online ahead of print. PMID: 36731883

Trevino TN, Almousawi AA, Ochoa-Raya A, Zemanski K, Oliveira SD, Marottoli FM, Tai LM, Minshall RD, Lutz SE. Endothelial Caveolin-1 and CXCL10 Promote Transcellular Migration of Autoreactive T Cells Across the Blood-Brain Barrier. BioRxiv (Preprint), 2023.

Cho H-D, Nhàn NTT, Zhou C, Tu K, Nguyen T, Sarich NA, and Yamada KH. KIF13B mediates VEGFR2 recycling to modulate vascular permeability. Cellular and Molecular Life Sciences 2023. https://doi.org/10.1007/s00018-023-04752-5.

End binding-3 inhibitor activates regenerative program in age-related macular degeneration.

Lee Q, Chan WC, Qu X, Sun Y, Abdelkarim H, Le J, Saqib U, Sun MY, Kruse K, Banerjee A, Hitchinson B, Geyer M, Huang F, Guaiquil V, Mutso AA, Sanders M, Rosenblatt MI, Maienschein-Cline M, Lawrence MS, Gaponenko V, Malik AB, Komarova YA. Cell Rep Med. 2023 Sep 26:101223. doi: 10.1016/j.xcrm.2023.101223. Online ahead of print. PMID: 37794584

Targeting EB3-IP3R3 Interface with Cognate Peptide Protects from Acute Respiratory Distress Syndrome.

Kwok ML, Geyer M, Chan WC, Zhao S, Gu L, Huang F, Vogel SM, Petukhov PA, Komarova Y. Am J Respir Cell Mol Biol. 2023 Oct;69(4):391-403. doi: 10.1165/rcmb.2022-0217OC. PMID: 37290041

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit.

Santana Nunez D, Malik AB, Lee Q, Ahn SJ, Coctecon-Murillo A, Lazarko D, Levitan I, Mehta D, Komarova YA. iScience. 2023 Apr 11;26(5):106661. doi: 10.1016/j.isci.2023.106661. eCollection 2023 May 19. PMID: 37168565

Tiruppathi C, Wang DM, Ansari MO, Bano S, Tsukasaki Y, Mukhopadhyay A, Joshi JC, Loch C, Niessen HWM, Malik AB. Ubiquitin Ligase CHFR Mediated Degradation of VE-cadherin through Ubiquitylation Disrupts Endothelial Adherens Junctions. Nat Commun 14, 6582 (2023). https://doi.org/10.1038/s41467-023-42225-2.

Kim K, Tseng A, Barazia A, Italiano JE, Cho J. DREAM plays an important role in platelet activation and thrombogenesis. Blood. 2017 Jan 12;129(2):209-225. doi: 10.1182/blood-2016-07-724419.

Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP. Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231.

Chatterjee I, Baruah J, Lurie EE, Wary KK. Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. Cardiovasc Res. 2016 Jul 1;111(1):105-18. doi: 10.1093/cvr/cvw090.

Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood. 2016 Feb 4;127(5):626-36. doi: 10.1182/blood-2015-04-638387.

Fu P, Ebenezer DL, Berdyshev EV, Bronova IA, Shaaya M, Harijith A, Natarajan V. Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. J Biol Chem. 2016 Dec 30;291(53):27187-27203. doi: 10.1074/jbc.M116.758946.

Gong H, An S, Sassmann A, Liu M, Mastej V, Mittal M, Zhang W, Hong Z, Offermanns S, Rehman J, Malik AB. PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells. Stem Cell Reports. 2016 Dec 13;7(6):1050-1058. doi: 10.1016/j.stemcr.2016.10.006.

Klomp JE, Huyot V, Ray AM, Collins KB, Malik AB, Karginov AV. Mimicking transient activation of protein kinases in living cells. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14976-14981. doi: 10.1073/pnas.1609675114.

Mittal M, Tiruppathi C, Nepal S, Zhao YY, Grzych D, Soni D, Prockop DJ, Malik AB. TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8151-E8158.

Rajput C, Tauseef M, Farazuddin M, Yazbeck P, Amin MR, Avin Br V, Sharma T, Mehta D. MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular Injury. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):380-8. doi: 10.1161/ATVBAHA.115.306997.

Tauseef M, Farazuddin M, Sukriti S, Rajput C, Meyer JO, Ramasamy SK, Mehta D. Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability. FASEB J. 2016 Jan;30(1):102-10. doi: 10.1096/fj.15-275891.

Zimnicka AM, Husain YS, Shajahan AN, Sverdlov M, Chaga O, Chen Z, Toth PT, Klomp J, Karginov AV, Tiruppathi C, Malik AB, Minshall RD. Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae. Mol Biol Cell. 2016 Jul 1;27(13):2090-106. doi: 10.1091/mbc.E15-11-0756.

Barazia A, Li J, Kim K, Shabrani N, Cho J. Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice. J Biol Chem. May 8, 2015.Blood. 2015 Nov 26;126(22):2511-7. doi: 10.1182/blood-2015-02-626234.

Chavez A, Schmidt TT, Yazbeck P, Rajput C, Desai B, Sukriti S, Giantsos-Adams K, Knezevic N, Malik AB, Mehta D. S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness. J Cell Sci. 2015 Mar 1;128(5):878-87. doi: 10.1242/jcs.154476.

Chignalia AZ, Vogel SM, Reynolds AB, Mehta D, Dull RO, Minshall RD, Malik AB, Liu Y. p120-catenin expressed in alveolar type II cells is essential for the regulation of lung innate immune response. Am J Pathol. 2015 May;185(5):1251-63. doi: 10.1016/j.ajpath.2015.01.022. Epub 2015 Mar 13.

Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik AB. Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction. J Cell Biol. April 13, 2015.

Melissa Geyer, Fei Huang, Ying Sun, Stephen M. Vogel, Asrar B. Malik, Colin W. Taylor, Yulia A. Komarova. Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca2+ Signaling in Endothelial Cells Cited in Scopus: 4. Cell Reports. 7 July 2015.

Gong H, Rehman J, Tang H, Wary K, Mittal M, Chaturvedi P, Zhao YY, Komarova YA, Vogel SM, Malik AB. HIF2alpha signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest. Mar 2, 2015.

Hart PC, Mao M, de Abreu AL, Ansenberger-Fricano K, Ekoue DN, Ganini D, Kajdacsy-Balla A, Diamond AM, Minshall RD, Consolaro ME, Santos JH, Bonini MG. MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nat Commun. Feb 5, 2015.

Kim K, Li J, Tseng A, Andrews RK, Cho J. NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation. Blood. 2015 Oct 15;126(16):1952-64. doi: 10.1182/blood-2014-10-605261.

Debroy A, Vogel SM, Soni D, Sundivakkam PC, Malik AB, Tiruppathi C. Cooperative signaling via transcription factors NF-kappaB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin. J Biol Chem. Aug 29, 2014.

Usatyuk PV, Fu P, Mohan V, Epshtein Y, Jacobson JR, Gomez-Cambronero J, Wary KK, Bindokas V, Dudek SM, Salgia R, Garcia JG, Natarajan V. Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem. May 9, 2014.

Karginov AV, Tsygankov D, Berginski M, Chu PH, Trudeau ED, Yi JJ, Gomez S, Elston TC, Hahn KM. Dissecting motility signaling through activation of specific Src-effector complexes. Nat Chem Biol. April 2014.

Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest. April 2014.

Gong H, Gao X, Feng S, Siddiqui MR, Garcia A, Bonini MG, Komarova Y, Vogel SM, Mehta D, Malik AB. Evidence of a common mechanism of disassembly of adherens junctions through Galpha13 targeting of VE-cadherin. J Exp Med. Mar 10, 2014.

Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD. G protein–dependent basal and evoked endothelial cell vWF secretion. Blood. 2014 123:442-450; doi: https://doi.org/10.1182/blood-2013-03-489351

Tiruppathi C, Soni D, Wang DM, Xue J, Singh V, Thippegowda PB, Cheppudria BP, Mishra RK, Debroy A, Qian Z, Bachmaier K, Zhao YY, Christman JW, Vogel SM, Ma A, Malik AB. The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nat Immunol. Mar 2014.

Wang Z, Li J, Cho J, Malik AB. Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils. Nat Nantechnol. Mar 2014.

Zhang X, Tan F, Skidgel RA. Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor. J Biol Chem. Nov 15, 2013.

Shen B, Zhao X, O'Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SC, Du X. A directional switch of integrin signalling and a new anti-thrombotic strategy. Nature. Nov 7, 2013.

Sundivakkam PC, Natarajan V, Malik AB, Tiruppathi C. Store-operated Ca2+ entry (SCOE) induced by protease-activated receptor-1 mediates STIM1 protein phoshorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38beta mitogen-activated protein kinase. J Biol Chem. June 7, 2013.

Rajput C, Kini V, Smith M, Yazbeck P, Chavez A, Schmidt T, Zhang W, Knezevic N, Komarova Y, Mehta D. Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions. J Biol Chem. Feb 8, 2013.

Lowry JL, Brovkovych V, Zhang Y, Skidgel RA. Endothelial nitric-oxide synthase activation generates an inducible nitric oxide synthase-like output of nitric oxide in inflamed endothelium. J Biol Chem. Feb 8, 2013.