PCOL 501 and 502  Medical Pharmacology I & II

Course Director:  Prasad Kanteti, PhD

Medical Pharmacology focuses on the molecular and cellular mechanisms whereby therapeutic drugs, or other pharmacologically or toxicologically  active compounds interact with biological, particularly human, systems. This year-long course covers the general principles of drug action, including drug absorption, distribution, metabolism, elimination, pharmcokinetics, and pharmacodynamics of important therapeutic drug categories. For each drug category, the course emphasizes: selected prototype drugs, molecular mechanisms of action, pharmacokinetic properties, therapeutics, adverse effects contra-indications and drug-drug interactions.

PCOL 501 (Spring Semester) covers General Principles, Chemotherapy of Infectious and Neoplastic Diseases, Autonomic Pharmacology, and Cardiovascular Drugs

PCOL 502 covers Toxicology, Autacoids and Inflammation, Endocrine Pharmacology and Pharmacology of the Central Nervous System

PCOL 510  Molecular Pharmacology of Platelets, Thrombosis and Vascular System*

Course Director:  Xiaoping Du, MD, PhD; Jaehyung 'Gus' Cho, PhD

This course provides in-depth lectures and training to graduate students in the pharmacological, physiological, biochemical, and functional aspects of blood platelets; molecular mechanisms of and therapeutic approaches to thrombosis, hemostasis and vascular biology; and molecular mechanisms of cell adhesion and intracellular signal transduction using blood platelets as model cells. Cardiovascular diseases associated with thrombosis are the No 1 cause of death in the US. The major objective of the course is to introduce students to the cutting edge research in the field of thrombosis, hemostasis and vascular biology and thus prepare them for a career in the field of increasingly demanding thrombosis research and anti-thrombotic drug development. This course also teaches students how to investigate the molecular and cellular mechanisms of signaling transduction, cell adhersion and excitation.

* offered odd years only

GCLS 515  Receptor Pharmacology and Cell Signaling

Course Director:  John O'Bryan, PhD

This is an advanced couse on the molecular pharmacology of signal transduction mechanisms in cells. The course includes an overview of receptor theory, hands-on data analysis, lectures on various receptor-mediated signaling mechanisms, student presentations and discussions of selected papers. The emphasis is to provide fundamental knowledge of molecular mechanisms of cell signaling, as well as to expose students to the most updated progress in the field. Major topics covered include: (1) Receptor Theory; (2) Signaling through G-protein coupled receptors, Heterotrimetic G proteins, Low molecular weight G proteins, Effectors and regulators of G-protein signaling pathways; (3) Signaling through enzyme-linked receptors, Receptors with tyrosine kinase activity, Cytokine receptor signaling; (4) Signaling through ion channels, and (5) Signaling through nuclear receptors. Crosslisted as NEUS 515.

PCOL 530 Pharmacology and Biology of the Vessel Wall*

Course Directors:  Kishore Wary, PhD; Richard D Minshall, PhD; Masuko Ushio-Fukai, PhD

This course provides students a comprehensive overview of vascular biology related to physiological and pathological functios and pharmacological approaches to treatment of cardiovascular diseases, focusing on the vascular system as a target for the development of new therapeutic agents. One goal of the course is to investigate, in depth, the unique and important functions of the endothelium, e.g., as an endocrine organ, in regulation to cell adhesion, regualtion of transport across the vascular wall, control of cell growth (angiogensis, smooth muscle cell proliferation) and blood cell interactions. In addition, the consequences of dysfunction of the endothelium and pharmacological interventions to treat cardiovascular diseases are studied.

*offered even years only

PCOL 540  Ion Channels: Structure, Function, Pharmacology and Pathology*

Course Directors:  Jesus Garcia-Martinez, MD, PhD; Irena Levitan, PhD

Ion channels are related not only to action potentials and synaptic potentials in the nervous system but have much broader and essential functions in normal physiology and cell biology. They also play important roles in the pathology of some diseases, and therapeutic effects of many drugs, including benzodiazepines, barbiturates, clozapine, alcohol and local and general anesthetics.

The main objective of the course is to offer future pharmacologists and other basic scientists in depth exposure to this rapidly developing area of science. Since the successful cloning of an ion chanel in 1982, our knowledge has progressed rapidly and in 1988, X-ray crystallography unraveled the tertiary structure of the protein and provided great insight into the mechanism by which ion channels function.

*offered even years only

PCOL 550  Biology and Pharmacology of the Lung

Course Director:  Dolly Mehta, PhD

Ion channels are related not only to action potentials and synaptic potentials in the nervous system. The overall goal of this course is to provide students a comprehensive overview of lung biology and function, the effect of impaired lung functions in inducing several pathologies and current therapeutic regimes. This course will cover topics in lung biology and physiology; e.g. lung structure and development, surfactant, lung volumes, lung cells, oxidant and NO signaling, and lung angiogenesis and will also describe the importance of impaired lung function in inducing lung diseases such as asthma, cystic fibrosis, edema, ARDS, cancer and TB. Lectures will also provide a description of current therapeutics for treating lung diseases which include gene and cell-based therapies.

*Required course for trainees in the Lung Biology and Pathobiology Training Program

(This does not count towards the Pharmacology elective requirement)

PCOL 560 Graduate Pharmacology

Course Director:   Oscar Colamonici, PhD; Nabeela Rehman, PhD

This course, unlike medical pharmacology, focuses on the mechanism of action of the most improtant drugs used for the treatment of specific diseases. It is tailored for graduate students whose main interest is the broad aspects of pharmacological sciences since it also covers new topics such as pharmacogenomics, drug discovery and development, animal models and targeted therapies.

PCOL 595  Pharmacology Seminar

Course Director:   Jaehyung "Gus" Cho, PhD; Yulia Komarova, PhD

Presentation of research and/or current literature by invited lecturers and students.

PCOL 599  PhD Thesis Research

Course Director:   Jaehyung "Gus" Cho, PhD; Yulia Komarova, PhD

Thesis work under the supervision of a graduate advisor.