RECENT NOTABLE PUBLICATIONS

Featured Publications


2017

Kim K, Tseng A, Barazia A, Italiano JE, Cho J. DREAM plays an important role in platelet activation and thrombogenesis. Blood. 2017 Jan 12;129(2):209-225. doi: 10.1182/blood-2016-07-724419.


Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP. Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231.


2016

Chatterjee I, Baruah J, Lurie EE, Wary KK. Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. Cardiovasc Res. 2016 Jul 1;111(1):105-18. doi: 10.1093/cvr/cvw090.


Estevez B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood. 2016 Feb 4;127(5):626-36. doi: 10.1182/blood-2015-04-638387.


Fu P, Ebenezer DL, Berdyshev EV, Bronova IA, Shaaya M, Harijith A, Natarajan V. Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. J Biol Chem. 2016 Dec 30;291(53):27187-27203. doi: 10.1074/jbc.M116.758946.


Gong H, An S, Sassmann A, Liu M, Mastej V, Mittal M, Zhang W, Hong Z, Offermanns S, Rehman J, Malik AB. PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells. Stem Cell Reports. 2016 Dec 13;7(6):1050-1058. doi: 10.1016/j.stemcr.2016.10.006.


Klomp JE, Huyot V, Ray AM, Collins KB, Malik AB, Karginov AV. Mimicking transient activation of protein kinases in living cells. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14976-14981. doi: 10.1073/pnas.1609675114.


Mittal M, Tiruppathi C, Nepal S, Zhao YY, Grzych D, Soni D, Prockop DJ, Malik AB. TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8151-E8158.


Rajput C, Tauseef M, Farazuddin M, Yazbeck P, Amin MR, Avin Br V, Sharma T, Mehta D. MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular Injury. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):380-8. doi: 10.1161/ATVBAHA.115.306997.


Tauseef M, Farazuddin M, Sukriti S, Rajput C, Meyer JO, Ramasamy SK, Mehta D. Transient receptor potential channel 1 maintains adherens junction plasticity by suppressing sphingosine kinase 1 expression to induce endothelial hyperpermeability. FASEB J. 2016 Jan;30(1):102-10. doi: 10.1096/fj.15-275891.


Zimnicka AM, Husain YS, Shajahan AN, Sverdlov M, Chaga O, Chen Z, Toth PT, Klomp J, Karginov AV, Tiruppathi C, Malik AB, Minshall RD. Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae. Mol Biol Cell. 2016 Jul 1;27(13):2090-106. doi: 10.1091/mbc.E15-11-0756.


2015

Barazia A, Li J, Kim K, Shabrani N, Cho J. Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice. J Biol Chem. May 8, 2015.Blood. 2015 Nov 26;126(22):2511-7. doi: 10.1182/blood-2015-02-626234.


Chavez A, Schmidt TT, Yazbeck P, Rajput C, Desai B, Sukriti S, Giantsos-Adams K, Knezevic N, Malik AB, Mehta D. S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness. J Cell Sci. 2015 Mar 1;128(5):878-87. doi: 10.1242/jcs.154476.


Chignalia AZ, Vogel SM, Reynolds AB, Mehta D, Dull RO, Minshall RD, Malik AB, Liu Y. p120-catenin expressed in alveolar type II cells is essential for the regulation of lung innate immune response. Am J Pathol. 2015 May;185(5):1251-63. doi: 10.1016/j.ajpath.2015.01.022. Epub 2015 Mar 13.


Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik ABRac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction. J Cell Biol. April 13, 2015.


Melissa Geyer, Fei Huang, Ying Sun, Stephen M. Vogel, Asrar B. Malik, Colin W. Taylor, Yulia A. Komarova. Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca2+ Signaling in Endothelial Cells Cited in Scopus: 4. Cell Reports. 7 July 2015.


Gong H, Rehman J, Tang H, Wary K, Mittal M, Chaturvedi P, Zhao YY, Komarova YA, Vogel SM, Malik ABHIF2alpha signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest. Mar 2, 2015.


Hart PC, Mao M, de Abreu AL, Ansenberger-Fricano K, Ekoue DN, Ganini D, Kajdacsy-Balla A, Diamond AM, Minshall RD, Consolaro ME, Santos JH, Bonini MGMnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nat Commun. Feb 5, 2015.


Kim K, Li J, Tseng A, Andrews RK, Cho J. NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation. Blood. 2015 Oct 15;126(16):1952-64. doi: 10.1182/blood-2014-10-605261.


2014

Debroy A, Vogel SM, Soni D, Sundivakkam PC, Malik AB, Tiruppathi CCooperative signaling via transcription factors NF-kappaB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin. J Biol Chem. Aug 29, 2014.


Usatyuk PV, Fu P, Mohan V, Epshtein Y, Jacobson JR, Gomez-Cambronero J, Wary KK, Bindokas V, Dudek SM, Salgia R, Garcia JG, Natarajan V. Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem. May 9, 2014.


Karginov AV, Tsygankov D, Berginski M, Chu PH, Trudeau ED, Yi JJ, Gomez S, Elston TC, Hahn KM. Dissecting motility signaling through activation of specific Src-effector complexes. Nat Chem Biol. April 2014.


Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho JNeutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest. April 2014.


Gong H, Gao X, Feng S, Siddiqui MR, Garcia A, Bonini MG, Komarova Y, Vogel SM, Mehta D, Malik ABEvidence of a common mechanism of disassembly of adherens junctions through Galpha13 targeting of VE-cadherin. J Exp Med. Mar 10, 2014.


Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD. G protein–dependent basal and evoked endothelial cell vWF secretion. Blood. 2014 123:442-450; doi: https://doi.org/10.1182/blood-2013-03-489351


Tiruppathi C, Soni D, Wang DM, Xue J, Singh V, Thippegowda PB, Cheppudria BP, Mishra RK, Debroy A, Qian Z, Bachmaier K, Zhao YY, Christman JW, Vogel SM, Ma A, Malik ABThe transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation. Nat Immunol. Mar 2014.


Wang Z, Li J, Cho J, Malik ABPrevention of vascular inflammation by nanoparticle targeting of adherent neutrophils. Nat Nantechnol. Mar 2014.


2013

Zhang X, Tan F, Skidgel RACarboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor. J Biol Chem. Nov 15, 2013.


Shen B, Zhao X, O'Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SC, Du XA directional switch of integrin signalling and a new anti-thrombotic strategy. Nature. Nov 7, 2013.


Sundivakkam PC, Natarajan V, Malik AB, Tiruppathi CStore-operated Ca2+ entry (SCOE) induced by protease-activated receptor-1 mediates STIM1 protein phoshorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38beta mitogen-activated protein kinase. J Biol Chem. June 7, 2013.


Rajput C, Kini V, Smith M, Yazbeck P, Chavez A, Schmidt T, Zhang W, Knezevic N, Komarova Y, Mehta DNeural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions. J Biol Chem. Feb 8, 2013.


Lowry JL, Brovkovych V, Zhang Y, Skidgel RAEndothelial nitric-oxide synthase activation generates an inducible nitric oxide synthase-like output of nitric oxide in inflamed endothelium. J Biol Chem. Feb 8, 2013.