Contact Info

OFFICE:  909 S Wolcott

              4094 COMRB

PH #:  (312) 996-1068


Anke Di, MD, PhD


Research Interests

The general interest of my research is to study the role of ion channels in lung inflammation and injury. Specific projects:

1. Study the role of potassium channel in regulating inflammasome activation and lung inflammation.

2. Study the role of trp channel (TRPM2) in regulating phagocytic cell function and lung inflammation.

3. Study the role of chloride channel (CFTR) in regulating the function of phagocytic cells (macrophages and dendritic cells) and lung inflammation.

4. Study the role of sphingosine kinase 1 (SPK1) in calcium signaling and lung inflammation.

5. Study the role of the mechanosensitive ion channel (Piezo1) in regulating endothelial barrier function and lung edema formation.

Selected Awards and Honors


Giles F. Filley Memorial Award in Respiratory Physiology and Medicine, The American Physiological Society

Selected Publications

Di A, Krupa B, Nelson DJ. Calcium-G protein interactions in the regulation of macrophage secretion. The Journal of Biological Chemistry, 2001, 276(40)37124-37132.

Di A, Krupa B, Bindokas VP, Chen Y, Brown ME, Palfrey HC, Naren AP, Kirk KL, Nelson DJ. Quantal release of free radicals during exocytosis of phagosomes. Nature Cell Biology, 2002, 4:279-285.

Di A, Nelson DJ, Bindokas V, Brown ME, Libunao F, Palfrey HC. Dynamin regulates focal exocytosis in phagocytosing macrophages. Molecular Biology of the Cell, 2003, 14: 2016-2028.

Di A, Brown ME, Deriy LV, Li C, Szeto FL, Chen Y, Huang P, Tong J, Naren AP, Bindokas V, Palfrey HC, Nelson DJ. (2006). CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nature Cell Biology, 2006, 8(9): 933-944.

Di A, Kawamura T, Gao XP, Tang H, Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB. A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. J Biol Chem. 2010, 285(21):15848-57.

Di A, Gao XP, Qian F, Kawamura T, Han J, Hecquet C, Ye RD, Vogel SM, Malik AB. The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol. 2011, 13(1):29-34.

Di A, Kiya T, Gong H, Gao X, Malik AB. Role of the phagosomal redox-sensitive TRP channel TRPM2 in regulating bactericidal activity of macrophages. J Cell Science. 2017, 130(4):735-744.